Each of us is allowed to have an opinion about things. In my view, the greatest Mass ever composed was the "Mille Regretz" by Cristóbal de Morales. My understanding is that Morales went back to the Mass years later and wrote "alternate" Sanctus movements and Agnus Dei movements. These "alternate" movements are . . . very special.
Cristóbal de Morales is usually mentioned along with Francisco Guerrero and Tomás Luis de Victoria as the trio of Spanish composers who typified 16th-century Spanish church polyphony. The Missa Mille regretz is based on the famous chanson of the same name by Josquin des Prez, and proved to be a favorite work of Charles V.
You may know Dr. Lorenzo Candelaria from UT-Austin (he has written for Sacred Music before). He is a genius with this music, and a good resource for us.
It's always struck me that Spanish music of this era is, as you say, a good introduction to sacred polyphony because it is "bridge music": there was much less of a disconnect between art and folk music back then.
One little caution: "Mille regretz may not be by Josquin. It has, of course, become a parlor game for musicologists to disattribute some Josquin favorites, and there is some discussion back and forth in the scholarship. The tenor of some of it is that it is such a good piece that it must be by Josquin. All that counts is that Morales thought it was by Josquin and that it is such a good piece. It is a pity that good pieces stop being performed when they stop being by Josquin.
I believe that Dr. Mahrt has explained (someplace) that this is a case of a great composer "elevating" a secular tune, not a secular tune "bringing down" a lofty piece of music.
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